Sildenafil CitrateĀ  is mostly prescribed for treating Erectile Dysfunction and high blood pressure in the lungs also called pulmonary arterial hypertension. It can also be used to treat other conditions.


Sildenafil Citrate is a phosphodiesterase type 5 also known as PDE5 inhibitor. Sildenafil Citrate works by relaxing and dilating the blood vessels in the body. This lowers the blood pressure in the lungs and helps to improve your ability to exercise. It works for erectile dysfunction by relaxing the blood vessels in the penis which increase blood flow. The recommended dosage for Sildenafil Citrate to treat ED is 50 mg daily. Although most doctors will start with a Sildenafil Citrate dosage of 25 mg and work up to higher doses if the patient does not respond.

When you shouldnt use Sildenafil Citrate:

  • you have any allergy to Sildenafil Citrate
  • you have PVOD also known as pulmonary veno-occlusive disease
  • you are taking nitrates
  • you take any another drugs that contains Sildenafil Citrate or other PDE5

Before using Sildenafil Citrate:

Some conditions can interact with Sildenafil Citrate. Consult with a doctor if you have any of the below conditions

  • if you are pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to any type of drugs
  • if you have a history of a priapism (prolonged Erections lasting over 4 hours)
  • if you have a history of certain eye problems that are caused by pressure.
  • if you have pulmonary hypertension caused by sickle cell anemia
  • if you are taking bosentan or medicine for erectile dysfunction (ED)

Some drugs will interact with Sildenafil Citrate.

  • Alpha-blockers, medicines for high blood pressure, nitrates (eg, isosorbide, nitroglycerin), or nitroprusside because severe low blood pressure with dizziness, light-headedness, and fainting may occur
  • Azole antifungals (eg, itraconazole, ketoconazole), H2 antagonists (eg, cimetidine), HIV protease inhibitors (eg, ritonavir, saquinavir), macrolide antibiotics (eg, erythromycin), or telithromycin because they may increase the risk of Sildenafil Citrate’s side effects
  • Barbiturates (eg, phenobarbital), bosentan, carbamazepine, efavirenz, nevirapine, phenytoin, rifabutin, or rifampin because they may decrease Sildenafil Citrate’s effectiveness

This is list is not exhaustive. Ask your doctor if Sildenafil Citrate could interact with other medicines that you are taking.